International Journal of Advanced Medical and Health Research

REVIEW ARTICLE
Year
: 2021  |  Volume : 8  |  Issue : 2  |  Page : 49--56

Transplantation in hepatocellular carcinoma - controversies and recommendations: A review of current literature


Ruchir Bhavsar, Sri Aurobindo Prasad Das, Naimish N Mehta 
 Department of Surgical Gastroenterology, HPB Surgery and Liver Transplantation, Sir Ganga Ram Hospital, New Delhi, India

Correspondence Address:
Dr. Naimish N Mehta
R. No. 2222, Liver Unit, 2nd Floor, SSRB, Sir Ganga Ram Hospital, New Delhi - 110 070
India

Hepatocellular carcinoma (HCC) is the principal cause of death in patients with cirrhosis and the third leading cause of cancer-related death. HCC is present in around 80% of cirrhotic livers. Tumor recurrence and chronic liver failure are causative factors for mortality in the long term. Early liver transplantation (LT) for HCC with a significant tumor mass was associated with a poor prognosis owing to tumor recurrence. The vast experience and effectiveness of transplantation for HCC have sparked debates over whether the Milan criteria are overly stringent. The idea of tumor “downstaging,” expanding the limitations of tumor size, choice of either living related donor or cadaver donor transplantation, along with posttransplant care and its importance in HCC, are presently at the heart of a heated dispute. The recommendations in this article have attempted to highlight some of the disputed issues surrounding LT in HCC and may help programs in managing such patients better.


How to cite this article:
Bhavsar R, Das SA, Mehta NN. Transplantation in hepatocellular carcinoma - controversies and recommendations: A review of current literature.Int J Adv Med Health Res 2021;8:49-56


How to cite this URL:
Bhavsar R, Das SA, Mehta NN. Transplantation in hepatocellular carcinoma - controversies and recommendations: A review of current literature. Int J Adv Med Health Res [serial online] 2021 [cited 2022 Nov 30 ];8:49-56
Available from: https://www.ijamhrjournal.org/article.asp?issn=2349-4220;year=2021;volume=8;issue=2;spage=49;epage=56;aulast=Bhavsar;type=0