|Year : 2017 | Volume
| Issue : 2 | Page : 88
Comment on “Cerebral venous thrombosis in an infant with pneumococcal meningitis”
Mahmood Dhahir Al-Mendalawi
Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq
|Date of Submission||01-Jul-2017|
|Date of Acceptance||06-Sep-2017|
|Date of Web Publication||28-Dec-2017|
Prof. Mahmood Dhahir Al-Mendalawi
Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Al-Mendalawi MD. Comment on “Cerebral venous thrombosis in an infant with pneumococcal meningitis”. Int J Adv Med Health Res 2017;4:88
I read with interest the case report by Jain et al. on cerebral venous thrombosis (CVT) occurring in a 35-day-old infant with pneumococcal meningitis. In contrast to the usually delayed development of CVT as a complication of pneumococcal meningitis, its early occurrence in this infant is interesting, and it needs to be explained. I presume that infection with human immunodeficiency virus (HIV) might be contributory in this patient. My presumption is based on the following points.
First, to the best of my knowledge, HIV infection is an important public health problem in India, where 3.6% of HIV infections are attributable to perinatal transmission. The available data indicate a HIV seroprevalence of 1.03% among antenatal women who underwent HIV testing. Hence, it would be relevant to know the HIV status of the mother of the studied infant. A possibility of vertical transmission of HIV infection to the infant can't be totally excluded.
Second, pneumococcus is an important cause of morbidity and mortality among HIV-infected pediatric population. The rate of severe and invasive pneumococcal disease among vertically HIV-infected children has been reported to be higher compared to uninfected children born to HIV-infected mothers and control children. In view of the protracted clinical presentation, early occurrence of CVT, and the aforementioned points, underlying HIV infection needs to be excluded in the reported infant.
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Conflicts of interest
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| References|| |
Jain P, Rameshkumar R, Satheesh P, Kaur H. Cerebral venous thrombosis in an infant with pneumococcal meningitis: A case report and review of literature. Int J Adv Med Health Res 2017;4:30-2. [Full text]
Correa M, Gisselquist D. Routes of HIV transmission in India: Assessing the reliability of information from AIDS case surveillance. Int J STD AIDS 2006;17:731-5.
Sibia P, Mohi MK, Kumar A. Seroprevalence of human immunodeficiency virus among antenatal women in one of the institute of Northern India. J Clin Diagn Res 2016;10:QC08-9.
Farley JJ, King JC Jr., Nair P, Hines SE, Tressler RL, Vink PE. Invasive pneumococcal disease among infected and uninfected children of mothers with human immunodeficiency virus infection. J Pediatr 1994;124:853-8.